Masterwork weapons favor any character that is seeking to deals lots of Physical damage, particularly those that also deal Strength backed damage. Because the rune gives an increase to the base damage, it is more helpful on powerful two-handed weapons. This also applies to the armor slot: since heavy armor starts with more Physical armor a percentage increase is exponentially more valuable than on light armor or robes. For Mystical Frames, Wits is handy for everyone since it increases Initiative...