What Are The Adverse Effects Of Cryosurgery? The liquid nitrogen application generally takes much less than a minute. The period of freeze time differs with the types of imperfections. For instance, solar lentigo, or solar flare, commonly freeze around 3 to 4 seconds due to the fact that melanocytes (cells in the skin that create pigment) are much more conscious cool injury. Right here, care is required to cover a little bit location around the border of the sore to avoid leftover pigmentation...