The TRT literature on adolescent males is limited on T-induced pubertal changes and growth. For example, there is little concrete evidence to guide the optimal timing for initiating T therapy in adolescents with either CDGP or hypogonadism . After initiation of puberty, T doses are gradually increased to mimic normal pubertal physiology over the course of 2 to 3 years until puberty is clinically completed and adult doses are reached. A body of pediatric literature supports that short-term use ...