If Outlook is NOT able to start in safe mode, then try the next proposed solution below, entitled Create a new Outlook profile. Despite the various avenues mentioned, the problem is identified only on RDS 2016 How to Fix Outlook stuck on loading profile (5 servers) with Office 2016. Curiously, there are no issues with PCs running Windows 10 or 11 and Outlook 2016, all within the AD. I initially had a script to remove the entire Outlook folder if date created was before the date of implementation...